Hemophilic Arthropathy.

Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy

Hemophilic arthropathy is the most common chronic complication in patients with hemophilia. The pathogenesis of hemophilic arthropathy involves the inflammatory processes associated with rheumatoid arthritis (RA). Determining the severity and/or progression of joint damage is crucial when evaluating the effect of treatment modalities. Identifying reliable biomarkers in the peripheral blood of p...

Total Knee Arthroplasty in Patients with Hemophilia: What Do We Know?

Total knee arthroplasty is considered as the treatment of choice for those with end stage hemophilic arthropathy.Compared to other patients undergoing TKA, these patients have specific features such as bleeding tendency, youngerage, pre-operative restricted range of motion (ROM), altered anatomy, and increased complications. This narrativereview of literature is going to inves...

HFE mutations in the pathobiology of hemophilic arthropathy.

Blood-induced joint disease: the pathophysiology of hemophilic arthropathy.

Arthropathy is a frequent and serious complication of repeated joint bleeding in patients with hemophilia, resulting in pain, deformity, and disability. Although the pathogenesis of hemophilic arthropathy has not been fully elucidated, it appears to have similarities with the degenerative joint damage that occurs in osteoarthritis and the inflammatory processes associated with rheumatoid arthri...

Unraveling hemophilic arthropathy.

In this issue of Blood, Acharya and colleagues provide evidence for the role of angiogenesis in the pathophysiology of hemophilic joint disease. Is this the linchpin that unravels this important clinical condition or merely a cog in a not so stepwise process?

Treatment of Hemophilic Ankle Arthropathy with One-Step Arthroscopic Bone Marrow–Derived Cells Transplantation

OBJECTIVE Ankle arthropathy is a frequent and invalidating manifestation of hemophilia. Arthrodesis is the gold standard surgical procedure in end-stage disease, with many drawbacks in young patients. Recent literature has shown increase interest in regenerative procedures in hemophilic arthropathy, which may be desirable to delay or even avoid arthrodesis. The aim of this article is to present...